Líneas de investigación

• Diagnóstico y epidemiología de enfermedades virales.
• Factores moleculares de patogenicidad y virulencia de paramixovirus.
• Mecanismos de patogenia del virus de la hepatitis C.
• Respuesta inmunitaria innata en la infección por virus de dengue.
• Aspectos moleculares y bioquímicos del virus de la influenza A.
• Desarrollo de agentes antivirales con potencial terapéutico en infecciones virales humanas (influenza, dengue, Zika, COVID-19).

Integrantes

Investigadores

D. en C. Julio Roberto Reyes Leyva, Investigador Titular C, SNI: Nivel III, julio.reyes@imss.gob.mx.
D. en C. Gerardo Santos López, Investigador Titular C, SNI: Nivel II, gerardo.santos.lopez@gmail.com.
D. en C. Francisca Sosa Jurado, Investigadora Asociada D, SNI: Nivel I, sosajurado@hotmail.com.

D. en C. Luis Márquez Domínguez, Investigador Asociado A, SNI. Candidato, lumardo80@gmail.com.

Tesistas de Doctorado
M. en C. Mario Alberto Cuapa González (IPN).

M. en C. Erick Acocal Juárez (BUAP)

M. en C. Getulio Flores Tlalpa (BUAP)

M. en C. Erándeni Lorena Martínez Jiménez (BUAP)

Tesistas de Maestría
LBM Araceli Romero Pérez (BUAP)

M.C. Janina Ninette Robles Minutti (BUAP)

Colaboradores Hospital General de Zona # 5, IMSS
Enf. Margarita Moreno Rocha
Q.F.B. Consuelo Manjarrez Morales

Colaboradores Coordinación de Investigación Delegacional, IMSS
Dra. Socorro Méndez Martínez
Dr. Jorge Ayón Aguilar

Colaboradores Unidad Médica de Alta Especialidad, Centro Médico Nacional "General de División Manuel Ávila Camacho", IMSS.
Dr. Daniel Meléndez-Mena
Dr. Miguel Ángel Mendoza-Torres
Dr. Víctor Hugo García y García
Q.F.B. Belinda Guzmán-Flores
Q.F.B. Maribel Bernal-Soto

Publicaciones recientes (2020-2024)

Para ver la lista completa de artículos en PubMed

http://www.ncbi.nlm.nih.gov/pubmed/?term=reyes-leyva+j

http://www.ncbi.nlm.nih.gov/pubmed/?term=sosa-jurado+f

http://www.ncbi.nlm.nih.gov/pubmed/?term=santos-lopez+g
https://www.ncbi.nlm.nih.gov/pubmed/?term=marquez-dominguez+l

Cuapa-Gonzalez MA, Santos-López G, Orduña-Díaz A, Martínez-Gutiérrez H, Rojas-López M. Detection of Zika virus by the development of a colloidal gold nanoparticle-based immunosensor. Anal Lett 2024; En prensa.

Santos-López G, Panduro A, Sosa-Jurado F, Fierro NA, Lira R, Márquez-Domínguez L, Cerbón M, Méndez-Sánchez N, Roman S. Advance in the elimination of viral hepatitis in Mexico: A local perspective on the global initiative. Pathogens 2024;13:859.

Acocal-Juárez E, Márquez-Domínguez L, Vallejo-Ruiz V, Cedillo L, Santos-López G. Baloxavir resistance markers in influenza A and B viruses in the Americas. Drug Healthc Patient Saf. 2024;16:105-113.

Rosas-Murrieta NH, Rodríguez-Enríquez A, Herrera-Camacho I, Millán-Pérez-Peña L, Santos-López G, Rivera-Benítez JF. Comparative review of the state of the art in research on the porcine epidemic diarrhea virus and SARS-CoV-2, scope of knowledge between coronaviruses. Viruses 2024;16(2): 238.

Gutiérrez-Chable LE, Lezama-Ávila FI, Ochoa Fuentes DA, García-Flores MA, Santos-López G, Méndez-Martínez S. Mpox en humanos: un panorama de la epidemia de 2022-2023. Rev Med Inst Mex Seguro Soc 2024;62(2):e5756.

Márquez-Domínguez L, Jasso-Miranda C, Sedeño-Monge V, Santos-López G. Non-analog compounds to sialic acid as inhibitors of influenza virus neuraminidase: An underexplored approach for novel antivirals. Sci Pharm 2024;92:33.

Rodríguez Alfaro SE, Méndez Martínez S, Guerrero Barrio S, Ayón Aguilar J, García Flores MA, Santos López G. Tendencias epidemiológicas del dengue en Latinoamérica y México: 2019-2024. Med Int Mex 2024;40(5):287-294.

Domínguez-Ramírez L, Sosa-Jurado F, Díaz-Sampayo G, Solis-Tejeda I, Rodríguez-Pérez F, Pelayo R, Santos-López G, Cortes-Hernandez P. Age and comorbidities as risk factors for severe COVID-19 in Mexico, before, during and after massive vaccination. Vaccines 2023;11(11):1676.

Márquez-Domínguez L, Márquez-Matla K, Reyes-Leyva J, Vallejo-Ruiz V, Santos-López G. Antiviral resistance in influenza viruses. Cell Mol Biol 2023;69(13):16-23.

Sosa-Jurado F, Palencia-Lara R, Xicoténcatl-Grijalva C, Bernal-Soto M, Montiel-Jarquin Á, Ibarra-Pichardo Y, Rosas-Murrieta NH, Lira R, Cortes-Hernandez P, Santos-López G. Donated Blood Screening for HIV, HCV and HBV by ID-NAT and the Residual Risk of Iatrogenic Transmission in a Tertiary Care Hospital Blood Bank in Puebla, Mexico. Viruses. 2023;15(6):1331.

Romo-Rodríguez R, Gutiérrez-de Anda K, López-Blanco JA, Zamora-Herrera G, Cortés-Hernández P, Santos-López G, Márquez-Domínguez L, Vilchis-Ordoñez A, Ramírez-Ramírez D, Balandrán JC, Parra-Ortega I, Resendis-Antonio O, Domínguez-Ramírez L, López-Macías C, Bonifaz LC, Arriaga-Pizano LA, Cérbulo-Vázquez A, Ferat-Osorio E, Chavez-González A, Treviño S, Brambila E, Ramos-Sánchez MÁ, Toledo-Tapia R, Domínguez F, Bayrán-Flores J, Cruz-Oseguera A, Reyes-Leyva JR, Méndez-Martínez S, Ayón-Aguilar J, Treviño-García A, Monjaraz E, Pelayo R. Chronic Comorbidities in Middle Aged Patients Contribute to Ineffective Emergency Hematopoiesis in Covid-19 Fatal Outcomes. Arch Med Res. 2023;54(3):197-210. 

Reyes-Vallejo T, Conde-Rodríguez I, Serna-Villalobos J, Ramírez-Díaz I, Pérez-Villalobos G, Delgado-López G, Vázquez-Zamora VJ, Gutierrez-Quiroz CT, Ávila-Jiménez L, García-Carrancá A, Martínez-Acosta L, Santos-López G, Reyes-Leyva J, Vallejo-Ruiz V. Response to Article "Serum Levels of Galectin-9 are Increased in Cervical Cancer Patients and are Higher in Advanced Clinical Stages" [Response to Letter]. Onco Targets Ther. 2022;15:1543-1544.

Reyes-Vallejo T, Conde-Rodríguez I, Serna-Villalobos J, Ramírez-Díaz I, Pérez-Villalobos G, Delgado-López G, Vazquez-Zamora VJ, Gutiérrez-Quiroz CT, Ávila-Jiménez L, García-Carrancá A, Martínez-Acosta L, Santos-López G, Reyes-Leyva J, Vallejo-Ruiz V. Serum Levels of Galectin-9 are Increased in Cervical Cancer Patients and are Higher in Advanced Clinical Stages. Onco Targets Ther. 2022;15:1211-1220.

Domínguez-Ramírez L, Solis-Tejeda I, Ayon-Aguilar J, Mayoral-Ortiz A, Sosa-Jurado F, Pelayo R, Santos-López G, Cortes-Hernandez P. Decrease in COVID-19 adverse outcomes in adults during the Delta and Omicron SARS-CoV-2 waves, after vaccination in Mexico. Front Public Health. 2022;10:1010256. 

Cruz-Arreola O, Orduña-Diaz A, Domínguez F, Reyes-Leyva J, Vallejo-Ruiz V, Domínguez-Ramírez L, Santos-López G. In silico testing of flavonoids as potential inhibitors of protease and helicase domains of dengue and Zika viruses. PeerJ 2022;10:e13650.

Silva J, Patricio F, Patricio-Martínez A, Santos-López G, Cedillo L, Tizabi Y, Limón ID. Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer's and Parkinson's Disease. Front Neurosci. 2022 May 3;16:867825. 

Estrada-Jiménez T, Flores-Mendoza L, Ávila-Jiménez L, Vázquez-Rodríguez CF, Sánchez-Burgos GG, Vallejo-Ruiz V, Reyes-Leyva J. Low Activation of CD8+ T Cells in response to Viral Peptides in Mexican Patients with Severe Dengue. J Immunol Res. 2022 Mar 25;2022:9967594.

Rodríguez-Enríquez A, Herrera-Camacho I, Millán-Pérez-Peña L, Reyes-Leyva J, Santos-López G, Rivera-Benítez JF, Rosas-Murrieta NH. Predicted 3D model of the M protein of Porcine Epidemic Diarrhea Virus and analysis of its immunogenic potential. PLoS One. 2022 Feb 9;17(2):e0263582.

Díaz-Sampayo G, Pérez-Hernández L, Rodríguez-Pérez F, Domínguez-Ramírez L, Santos-López G, Cortés-Hernández P. Propagación y epidemiología de SARS-COV-2 tras un año de pandemia. ¿Qué debemos aprender para futuras crisis? En: Covarrubias Salvatori VG, Sánchez Flores L, Sánchez Flores O (coordinadores). Temas emergentes del COVID-19. Consejo de Ciencia y Tecnología del Estado Puebla. Puebla, Puebla, Mexico. 2021. pp. 267-294. ISBN: 978-607-99273-0-1. 

Aguirre-Alarcón HA, Heredia-Méndez AJ, Cortez-Sánchez JL, Bautista-Rodríguez E, Cortés-Hernández P, Santos-López G. Posible origen de SARS-CoV-2. En: Bautista Rodriguez E, Santos López G, Covarrubias Salvatori VG (coordinadores). Impacto de SARS-CoV-2/COVID-19: un enfoque interdisciplinario. Consejo de Ciencia y Tecnología del Estado Puebla. Puebla, Puebla, México. 2021. pp 1-11. ISBN: 978-607-99058-8-0.

Santos-López G, Cortés-Hernández P, Melgarejo de Gante F, Vallejo-Ruiz V. Coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2): características estructurales, moleculares y ciclo replicativo. En: Bautista Rodríguez E, Santos López G, Covarrubias Salvatori VG (coordinadores). Impacto del SARS-CoV-2/COVID-19: un enfoque interdisciplinario. Consejo de Ciencia y Tecnología del Estado Puebla. Puebla, Puebla, México. 2021. pp 15-27. ISBN: 978-607-99058-8-0.

Bautista Rodríguez E, Santos López G, Covarrubias Salvatori VG (Ed.). Impacto del SARS-CoV-2/COVID-19: un enfoque interdisciplinario. Consejo de Ciencia y Tecnología del Estado de Puebla. Puebla, México, 2021. ISBN: 978-607-99058-8-0.

Moreno-Córdova V, Berra-Romani R, Flores Mendoza LK, Reyes-Leyva J. Th17 Lymphocytes in Children with Asthma: Do They Influence Control? Pediatr Allergy Immunol Pulmonol. 2021 Dec;34(4):147-152.

Rivera-Benítez JF, De la Luz-Armendáriz J, Gómez-Núñez L, Diosdado VF, Socci EG, Ramírez-Medina E, Velázquez-Salinas L, Ramírez-Mendoza H, Coba AMA, Tufiño-Loza C, Macías GM, Carrera-Aguirre V, Martínez-Bautista R, Martínez-Mercado MJ, Santos-López G, Herrera-Camacho I, Siañez-Estrada I, Zapata MM. Salud porcina: historia, retos y perspectivas. Rev Mex Cienc Pecu 2021; 12(Supl 3):149-185.

Rojas-Sanchez G, García-Miranda A, Montes-Alvarado JB, Cotzomi-Ortega I, Sarmiento-Salinas FL, Jimenez-Ignacio EE, Ramírez-Ramírez D, Romo-Rodríguez RE, Reyes-Leyva J, Vallejo-Ruiz V, Pazos-Salazar NG, Maycotte P. Chloroquine Induces ROS-mediated Macrophage Migration Inhibitory Factor Secretion and Epithelial to Mesenchymal Transition in ER-positive Breast Cancer Cell Lines. J Mammary Gland Biol Neoplasia. 2021 Nov 23. doi: 10.1007/s10911-021-09503-5.

Meléndez-Mena D, Mendoza-Torres MA, Sedeño-Monge V, García y García VH, Rivera García EN, Sánchez-Reza L, Baxin-Dominguez MC, Guzmán-Flores B, Martínez-Laguna Y, Coronel-Espinoza JM, Galindo-Santiago I, Flores-Alonso JC, Vallejo-Ruiz V, Cortés-Hernández P, Reyes-Leyva J, Sosa-Jurado F, Santos-López G. Effectiveness, tolerability and safety to Direct Acting Antivirals in Mexican individuals with Hepatitis C virus genotype-1 and previous Pegylated Interferon and Ribavirin therapy. PeerJ 2021;9:e12051

Sosa-Jurado F, Sánchez-Reza L, Mendoza-Torres MA, Meléndez-Mena D, García VHG., Guzmán-Flores B, Enciso-Moreno JA, López-Ramos JE, Juárez JCB, Vallejo-Ruiz V, Cortes-Hernández P, Reyes-Leyva J, Santos-López G. Serum Th17 profile and TNF- distinguish between occult hepatitis B infection, chronic hepatitis B infection and healthy individuals. Eur Cytokine Netw 2021;32(2):23-30.

Arciga-Vázquez GS, Santos-López G, Castañeda-Roldán EI, Cedillo-Ramírez ML, Cano-Vázquez EN, Monroy-Azuara MG, López-Méndez AI, Ayón-Aguilar J, Méndez-Martínez S. Estudio de casos confirmados de brucelosis humana en Puebla, México. Rev Chilena Infectol 2021;38(2):281-289. 

Cotzomi-Ortega I, Nieto-Yañez O, Juárez-Avelar I, Rojas-Sanchez G, Montes-Alvarado JB, Reyes-Leyva J, Aguilar-Alonso P, Rodriguez-Sosa M, Maycotte P. Autophagy inhibition in breast cancer cells induces ROS-mediated MIF expression and M1 macrophage polarization. Cell Signal. 2021 Oct;86:110075. 

Santos-Lopez G, Cortés-Hernández P, Vallejo-Ruiz V, Reyes-Leyva J. SARS-CoV-2: generalidades, origen y avances en el tratamiento. Gac Med Mex 2021;157:88-93.

García-Miranda A, Solano-Alcalá KA, Montes-Alvarado JB, Rosas-Cruz A, Reyes-Leyva J, Navarro-Tito N, Maycotte P, Castañeda-Saucedo E. Autophagy Mediates Leptin-Induced Migration and ERK Activation in Breast Cancer Cells. Front Cell Dev Biol. 2021 Mar 8;9:644851.

Sedeño-Monge V, Laguna-Meraz S, Santos-López G, Panduro A, Sosa-Jurado F, Jose-Abrego A, Meléndez-Mena D, Muñoz-Ramírez MA, Cosme-Chávez M, Roman S. A comprehensive update of the status of hepatitis C virus (HCV) infection in Mexico-a systematic review and meta-analysis (2008-2019). Ann Hepatol 2021;(20):100292.

Oliveros-Montiel A, Santos-López G, Sedeño-Monge V. Proteins involved in lipid metabolism as possible biomarkers or predisposing factors for non-alcoholic fatty liver disease. Acta Gastroenterol Belg. 2020 Oct-Dec;83(4):622-630.

Cisneros-Ramírez D, Martínez-Laguna Y, Martínez-Morales P, Aguilar-Lemarroy A, Jave-Suárez LF, Santos-López G, Reyes-Leyva J, Vallejo-Ruiz V. Glycogene expression profiles from a HaCaT cell line stably transfected with HPV16 E5 oncogene. Mol Med Rep. 2020 Dec;22(6):5444-5453.

Armenta-Castro E, Reyes-Vallejo T, Máximo-Sánchez D, Herrera-Camacho I, López-López G, Reyes-Carmona S, Conde-Rodríguez I, Ramírez-Díaz I, Aguilar-Lemarroy A, Jave-Suárez LF, Milflores-Flores L, Santos-Lopez G, Reyes-Leyva J, Vallejo-Ruiz V. Histone H3K9 and H3K14 acetylation at the promoter of the LGALS9 gene is associated with mRNA levels in cervical cancer cells. FEBS Open Bio. 2020 Sep 9. doi: 10.1002/2211-5463.12973.

Siañez-Estrada LI, Rivera-Benítez JF, Rosas-Murrieta NH, Reyes-Leyva J, Santos-López G, Herrera-Camacho I. Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus. PLoS One. 2020 Sep 25;15(9):e0239785. 

Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020 Sep 16;25(18):E4248. 

Martínez-Morales PL, Ortiz-Mateos CA, Reyes-Pineda J, Reyes-Vallejo T, Aguilar-Lemarroy A, Jave-Suárez LF, Santos-López G, Reyes-Leyva J, Milflores-Flores L, Vallejo-Ruiz V. Identification and characterization of the V3 promoter of the ST3GAL4 gene. Biosci Trends. 2020;14(2):144-150.

Cárdenas-Perea ME, Flores-Mendoza LK, Pérez-Contreras I, Díaz-Orea MA, Gómez-Conde E, Cortés-Hernández P, Reyes-Leyva J, Santos-López G, Sosa-Jurado F. Primary Dengue Infection in Patients Requiring Hospitalization During an Outbreak in a Low Incidence Mexican Region. Vector Borne Zoonotic Dis. 2020;20(5):380-386.

Cotzomi-Ortega I, Rosas-Cruz A, Ramírez-Ramírez D, Reyes-Leyva J, Rodriguez-Sosa M, Aguilar-Alonso P, Maycotte P. Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer. Biology (Basel). 2020;9(1):20. 

Rojas-Morales E, Santos-López G, Hernández-Cabañas S, Arcega-Revilla R, Rosas-Murrieta N, Jasso-Miranda C, El-Kassis EG, Reyes-Leyva J, Sedeño-Monge V. Differential Transcription of SOCS5 and SOCS7 in Multiple Sclerosis Patients Treated with Interferon Beta or Glatiramer Acetate. Int J Mol Sci. 2020;21(1):218.